1st image left panel; Painful neuroma showing immunostaining for the Cannabinoid receptor subtype 2 (CB2), a novel pain drug target;

1st image right panel; Neurofilaments immunostaining in the painful neuroma. Magnification x20.

Image credit Professor P Anand (Hammersmith Hospital & Imperial University)

 

2nd image left panel, Nerve Growth Factor (NGF) staining of basal epithelial cells in human skin. Magnification x20.

2nd image right panel, Regenerating nerve marker GAP-43 immunoreactive nerve fibres running along the NGF-rich basal epidermal – dermal junction (arrowed) in skin from a patient with painful neuropathy. Magnification x40

Image credit Professor P Anand (Hammersmith Hospital & Imperial University)

 

3rd image Heat and Capsaicin receptor TRPV1 immunoreactivity in small/medium diameter neurons and nerve fibres in an avulsed injured human cervical dorsal root ganglion (DRG). Magnification x20.

Image credit Professor P Anand (Hammersmith Hospital & Imperial University)

 

4th image Left panel, Intra-epithelial and sub-epithelial fibres from the leg skin of a patient who underwent amputation after complex limb nerve injury with chronic pain, immunostained with antibody to TRPV1, the heat and capsaicin receptor; there is marked increase of thickened TRPV1 nerve fibres. Magnification x40.

4th image Right panel, TRPV1 axonal neuronal fibre staining in the superficial peroneal nerve of the same patient. Magnification x20.

 

Image credit Professor P Anand (Hammersmith Hospital & Imperial University)